Detalles de la búsqueda
1.
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell;
165(3): 643-55, 2016 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27104980
2.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Mol Cell;
79(1): 180-190.e4, 2020 07 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32619468
3.
B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
Proc Natl Acad Sci U S A;
111(8): 3122-7, 2014 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24516162
4.
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Bioorg Med Chem;
24(4): 521-44, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26762835
5.
Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.
Org Biomol Chem;
11(12): 1964-77, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23386308
6.
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.
Cancer Cell;
7(3): 275-86, 2005 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15766665
7.
Screening candidate anticancer drugs for brain tumor chemotherapy: pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analogues.
Invest New Drugs;
30(6): 2263-73, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22383114
8.
Preclinical pharmacokinetic and pharmacodynamic evaluation of novel anticancer agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for brain tumor chemotherapy.
Pharm Res;
29(9): 2499-511, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22678771
9.
Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.
Bioorg Med Chem;
18(6): 2317-2326, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20188579
10.
Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms.
Radiat Res;
171(2): 173-9, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19267542
11.
NiO decorated CeO2 nanostructures as room temperature isopropanol gas sensors.
RSC Adv;
9(24): 13765-13775, 2019 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-35519582
12.
Effect of vanadium pentoxide concentration in ZnO/V2O5 nanostructured composite thin films for toluene detection.
RSC Adv;
9(29): 16515-16524, 2019 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35516390
13.
Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.
J Med Chem;
51(1): 86-100, 2008 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18088089
14.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Bioorg Med Chem;
16(7): 3907-16, 2008 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18272371
15.
Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma.
Cancer Res;
76(5): 1225-36, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26873845
16.
Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.
Eur J Cancer;
50(11): 1982-92, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24835034
17.
Preclinical pharmacological evaluation of a novel multiple kinase inhibitor, ON123300, in brain tumor models.
Mol Cancer Ther;
13(5): 1105-16, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24568969
18.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
J Med Chem;
57(3): 578-99, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417566
19.
ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway.
PLoS One;
8(3): e58355, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23505494
20.
Integrated pharmacokinetic-driven approach to screen candidate anticancer drugs for brain tumor chemotherapy.
AAPS J;
15(1): 250-7, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23180160